Advances in Drug Research

Cover

Contents

Contributors

Preface: Circles in drug research

Chapter 1. Stereochemical Aspects of Drug Action and Disposition

1 Introduction

2 Stereoselectivity in Drug Action

3 Stereoselectivity in Drug Disposition

4 Stereoselectivity and Toxicity

5 Implications and Consequences

6 Drug Development

7 Conclusion

References

Chapter 2. Advances in the Development of Pharmaceutical Antioxidants

1 Introduction

2 Endogenous Defence Systems

3 Semisynthetic Analogues of Endogenous Antioxidants

4 Natural Products

5 Synthetic Antioxidants

6 Clinical Agents

7 Conclusions

Acknowledgements

References

Chapter 3. Multidrug Resistance of Cancer Cells

1 Introduction and Overview

2 MDR1 and Clinical Multidrug Resistance

3 Mechanism of Action of the MDR1 Gene Product

4 MDR1 Gene Regulation

5 Other Mechanisms of Multidrug Resistance

6 Prospects for Pgp-related Chemotherapy

Acknowledgements

References

Chapter 4. Bioactivation of Organic Nitrates and Other Nitrovasodilators

1 Introduction

2 Nitric Oxide and Cyclic GMP as Meditiaiors of Organic Nitrate Action

3 Nitric Oxide Formation from Organic Nitrates in Cell-free Systems

4 Cytochrome P450 as a Mediator of Nitric Oxide Formation from Organic Nitrates in Intact Cells

5 Unanswered Questions

6 Outlook

References

Chapter 5. The Vitamin D Endocrine System and its Therapeutic Potential

1 Historical Introduction

2 Biosynthesis of Vitamin D

3 Metabolism of Vitamin D

4 Mechanism of Action of 1,25-(OH)2D3

5 Functions of Vitamin D

6 Regulation of the Vitamin D Endocrine System

7 Therapeutic Uses of Vitamin D Metabolites and Analogues

8 Conclusions and Future Directions

Acknowledgements

References

Chapter 6. Dopamine Receptors : Studies on Structure and Function

1 Multiple Dopamine Receptors

2 Common Properties of Dopamine Receptor Subtypes Defined by Molecular Biology

3 Distinct Properties of the Dopamine Receptor Subtypes Defined by Molecular Biological Techniques

4 The Mechanism of Binding of Ligands to Dopamine Receptors

5 Conclusions

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles