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Miyoshi_Frontmatter_O.pdf
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Miyoshi_Ch01_O.pdf
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Part I: Clinical Manifestations of Neuropsychiatric Disorders
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Introduction
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Neuropsychiatric Symptoms and Neuropsychiatric Disorders
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Characteristics of Clinical Manifestations of Neuropsychiatric Disorders
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Multiple Neuropsychiatric Symptoms Occur Simultaneously
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Probable and Possible Symptoms of Neuropsychiatric Disorders
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Neuropsychiatric Symptoms Could Be the Earliest Symptomsin Cerebral Disorders
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Neuropsychiatric Symptoms Are Not Pathognomonic to a Certain Cerebral Disorder
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Neuropsychiatric Symptoms May Mimic Endogenous Psychoses
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Neuropsychiatric Symptoms and Syndromes
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Anxiety and Neurotic Complaints
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Apathy
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Mood Disorder
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Hallucinations and Delusions
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Behavioral and Personality Changes
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Delirium
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Persistent Cognitive Impairment (Dementia)
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Dementia of the Alzheimer Type
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Neurodegenerative Dementias of Non-Alzheimer Type
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Vascular Cognitive Impairment
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Conclusions
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References
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Miyoshi_Ch02_O.pdf
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Thyroid–Brain Interactions in Neuropsychiatric Disorders
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Introduction
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Thyroid Axis Hormone Secretion and Metabolism
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Thyroid Hormone Transport to the Brain
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Thyroid Hormone Receptors and Homeostasis in the Brain
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Fetal Thyroid Economy and Development of the Brain
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MCT-8 Mutations and Neurodevelopment
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Hypothyroidism and Mental Function in Adults
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Treatment of Hypothyroidism
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Hyperthyroidism and Mental Symptoms in Adults
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Treatment of Hyperthyroidism
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Low T3 Syndrome in Mental Disorders
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Thyroid Autoimmunity and Mood Disorders
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Thyroid Function in Mood Disorders
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Thyroid Abnormalities and Schizophrenia
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Thyroid Axis Hormones in Treatment of Mental Disorders
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Thyroid Hormones
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Thyrotropin-Releasing Hormone
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Conclusion
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References
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Miyoshi_Ch03_O.pdf
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Lack of Insight and Awareness in Schizophrenia and Neuropsychiatric Disorders
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Introduction
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Insight into Psychiatric Disorders (Schizophrenia)
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Awareness and Symptomatology
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Clinical and Demographic Factors
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Awareness and Neurocognition
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Neuroimaging
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Mood
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Insight and Awareness in Alzheimer’s Disease
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Insight and Awareness in Brain Injury
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Direct Comparison of Insight and Awareness in Patients with Schizophrenia, AD, and Brain Injury
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Participants
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Methods
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Results
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Between-Group Contrasts
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Pooled Patient Analysis
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Summary and Conclusions
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References
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Miyoshi_Ch04_O.pdf
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Visual Hallucinations in Neurodegenerative Disorders
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Introduction
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Visual Hallucinations in Synucleinopathies
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Dementia with Lewy Bodies
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Epidemiology
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Factors Associated with VH in DLB
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Clinical Characteristics of VH in DLB
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Clinical Impact and Treatment of VH in DLB
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Parkinson’s Disease
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Epidemiology
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Factors Associated with the Presentation of Hallucinations in PD
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Clinical Characteristics of VH in PD
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Clinical Impact and Treatment of VH in PD
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Multiple System Atrophy
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VH in Tauopathies
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Alzheimer’s Disease
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Epidemiology
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Factors Associated with the Presentation of Hallucinations in AD
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Clinical Characteristics of VH in AD
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Clinical Impact and Treatment of VH in AD
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Progressive Supranuclear Palsy
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Frontotemporal Dementia
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VH in Heredodegenerative and Other Neurodegenerative Diseases
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Conclusions
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References
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Miyoshi_Ch05_O.pdf
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Organic Delusional Syndrome: Tentative Neuropsychological Mechanism of Delusions
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Introduction
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Persecutory Delusion and Delusional Perception in PDFTBI
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Delusional Misidentification Syndrome: Capgras Syndrome
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Anosognosia and Somatoparaphrenia
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Conclusion
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References
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Miyoshi_Ch06_O.pdf
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Neurological and Psychological Formsof Amnesia
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Introduction
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Transient Neurological Amnesias
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Transient Global Amnesia
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Transient Epileptic Amnesia
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Persistent Neurological Memory Disorders
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The Korsakoff Syndrome
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Herpes Encephalitis
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Confabulation
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Transient Psychogenic Amnesia
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Psychogenic Fugue
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Situation-Specific Amnesia
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Persistent Psychogenic Amnesia
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Conclusions
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References
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Miyoshi_Ch07_O.pdf
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The Neuropsychological Aspect of Epilepsy
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Discussion and Conclusion
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References
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Miyoshi_Ch08_O.pdf
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The Interictal Dysphoric Disorder of Epilepsy
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Epilepsy and Depression: An Overview
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Is Depression Associated with Any Specific Epilepsy Syndrome?
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Is There a Mood Disorder Specific of Epilepsy? The Interictal Dysphoric Disorder
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Diagnosing Mood Disorders in Patients with Epilepsy
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Conclusions
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References
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Miyoshi_Ch09_O.pdf
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Neuropsychiatric Symptoms of Seizure Disorders with Special Reference to the Amygdala
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Introduction
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The Amygdala
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The Amygdala in Epilepsy
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Structural Changes
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Functional Studies
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Conclusions
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References
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Miyoshi_Ch10_O.pdf
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Neuropsychiatric Assessment of Traumatic Brain Injury During Acute Neurorehabilitation*
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Introduction
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Defining TBI
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Characterizing TBI Severity
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Neurobiology of TBI
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Brain–Behavior Relationships and TBI
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Posttraumatic Encephalopathy
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Neuropsychiatric Evaluation of TBI in the Acute Rehabilitation Setting
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Bedside Assessment Methods
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Neurodiagnostic Methods
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Review of Concurrently Prescribed Treatments
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Conclusion
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References
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Miyoshi_Ch11_O.pdf
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Neuropsychiatric Aspects of Vascular Cognitive Impairment
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Background
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Neuropsychiatric Disorders Associated with Cognitive Impairment
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Alzheimer’s Disease
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Depression
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Psychotic Symptoms
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Cerebrovascular Diseases Associated with Cognitive Impairment and Neuropsychiatric Conditions
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Stroke
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Silent Infarcts
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White Matter Lesions
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Mixed Pathology
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Conclusion
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References
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Miyoshi_Ch12_O.pdf
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Neuropsychiatric Complications of Cerebrovascular Disease
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Introduction
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Mania
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Anxiety
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Apathy
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Disturbance of the Sleep–Wake Cycle
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Fatigue
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Sexual Dysfunction
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Cognitive Performance
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Involuntary Emotional Expression Disorder
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Irritability
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Psychosis
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Agitation
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Depression
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Conclusion
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References
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Miyoshi_Ch13_O.pdf
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Systemic Inflammation and Cognition in the Elderly
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Introduction
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Background
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Inflammation and Alzheimer’s disease
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“Inflammaging”
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Cross-Sectional Studies
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Longitudinal Studies
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Discussion
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Conclusion
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References
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Miyoshi_Ch14_O.pdf
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Diagnosis and Clinical Relevance of Depression and Apathy in Alzheimer’s Disease
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Depression in Alzheimer’s Disease
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Diagnosis of Depression in AD
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Diagnostic Criteria for Depression in AD
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Frequency of Depression in AD
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Clinical Correlates of Depression in AD
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Conclusion
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Apathy in AD
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Diagnosis of Apathy in AD
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Differential Diagnosis of Apathy in AD
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Frequency of Apathy in AD
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Clinical Correlates of Apathy in AD
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Conclusions
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References
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Miyoshi_Ch15_O.pdf
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Cognitive Decline and Treatment of Alzheimer’s Disease
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Treatment of AD
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Specific Goals of Treatment
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Restoring Neuronal Function
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Preventing Synapse and Cell Death
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Treatment of the Primary Cognitive Symptoms
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Cholinergic Agents
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Acetylcholine Precursors
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Acetylcholinesterase Inhibitors
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Glutamate Regulators
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Antioxidants
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Antiinflammatory Drugs
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Estrogen Replacement Therapy
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Neurotrophic Factors
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Treatment of Secondary Noncognitive Symptoms
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New Nonpharmacological Possibilities of Treatment
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References
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Miyoshi_Ch16_O.pdf
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Alzheimer’s Disease in Japan: Current Situation and Issues of the Care for Persons with Dementia
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Introduction
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Early Detection and Diagnosis
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Supporting the Human Rights of Persons with Dementia
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Issues for the Future
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References
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Miyoshi_Ch17_O.pdf
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AD-FTLD Spectrum: New Understanding of the Neurodegenerative Process from the Study of Risk Genes
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Genes for AD and FTLD
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Progranulin and TDP-43
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Copy Number Variation, miRNA, and Neurodegeneration
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AD-FTLD Spectrum
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References
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Miyoshi_Ch18_O.pdf
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Dementia with Lewy Bodies
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Introduction
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Pathology and Etiology
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Clinical Features
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Investigations
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Diagnostic Criteria
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References
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Miyoshi_Ch19_O.pdf
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Dementia with Lewy Bodies and Parkinson Disease with Dementia Within the Spectrum of Lewy Body Disease
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Introduction
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History of PD and DLB
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DLB and PDD Within the Spectrum of Lewy Body Disease
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References
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Miyoshi_Ch20_O.pdf
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Clinicopathological Characterizationof Frontotemporal Lobar Degeneration
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Introduction
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Pick Disease
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FTLD-LDH
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FTLD-MND
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Comments
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References
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Miyoshi_Ch21_O.pdf
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Diffuse Neurofibrillary Tangles with Calcification
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Introduction
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Case Presentation
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Epidemiology of DNTC
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Characteristics of Clinical Symptoms
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Pathological Characteristics
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NFTs
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Characteristics of Degenerative Tau Protein
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Electron Microscopy Findings
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Calcification
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Cerebrovascular Lesions
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Lewy Body Pathology
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Conclusion
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References
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Miyoshi_Ch22_O.pdf
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Ayahuasca: Current Interest in an Ancient Ritual
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Introduction
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Description of an Ayahuasca Ceremony
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Conclusions
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References
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Miyoshi_Ch23_O.pdf
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The Molecular Genetics of Suicide
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Introduction
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Molecular Genetics of Suicide
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Conclusion
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References
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Miyoshi_Ch24_O.pdf
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Brief History and Current Status of the International Neuropsychiatric Association
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Introduction
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The Beginning: The First Congress in Seville
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The Reorganization: The Second Congress in Toronto
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The Springboard: The Third Congress in Kyoto
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The Jump: The Fourth Congress in Buenos Aires
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The Collaborations: The Fifth Congress in Athens
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The Widening: The Sixth Congress in Sydney
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The Latest: The Seventh Congress in Cancun
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Regional Activities
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The Coming INA Meetings
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Current Status of the INA
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Officers and INA Office
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Executive Committee
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International Committee
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Awards
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Journal
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Relationships to National Neuropsychiatric Associations
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Future Direction
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Miyoshi_Ch25_O.pdf
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Core Curriculum in Neuropsychiatry of the International Neuropsychiatric Association*
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Background
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Goals of the Training Program
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Structure of the NP Training Program
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Objectives
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Attitude Objectives
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Knowledge Objectives
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Skills Objectives
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A Survey of Required Competencies in Neuropsychiatry
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Core Skills Module
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Specific Competencies
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Knowledge Base in Neuroscience
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Clinical Skills in Neuropsychiatry
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Critical Thinking in Neuropsychiatry: Research and Scholarship
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Specific Modules
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Module 2.1: Cognitive Disorders
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Specific Competencies
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Diagnostic Techniques
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Be familiar with the main principles involved in the management and treatment of cognitive disorders and of dementias
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How Taught
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How Assessed
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Module 2.2: Seizure Disorders
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Specific Competencies
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Module 2.3: Movement Disorders
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Specific Competencies
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Suggested Learning Methods
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Suggested Assessment Method: Clinic Logbook
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Module 2.4: Traumatic Brain Injury
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Clinical Settings
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Specific Competencies
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Suggested Learning Methods
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Module 2.5: Secondary Psychiatric Syndromes and Delirium
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Clinical Settings
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Specific Competencies
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Suggested Learning Methods
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Module 2.6: Substance-Induced Neuropsychiatric Syndromes
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Clinical Settings
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Specific Competencies
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Suggested Learning Methods
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Module 2.7: Attentional and Dysexecutive Syndromes (Including Adult ADHD)
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Clinical Settings
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Specific Competencies
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Suggested Learning Methods
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Module 2.8: General Hospital Liaison Neuropsychiatry
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Key Competencies
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Learning and Assessment Methods
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Module 2.9: Developmental Neuropsychiatry
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Preamble
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Skills in Developmental Neuropsychiatry
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Specific Competencies
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Learning and Assessment Methods
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Module 2.10: Sleep Disorders
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Specific Competencies
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Diagnostic Techniques
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Management
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Suggested Learning Methods
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Suggested Assessment Methods
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Module 2.11: Rehabilitation Neuropsychiatry
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Clinical Settings
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Knowledge
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Skills
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Learning and Assessment Methods
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Module 2.12: Forensic Neuropsychiatry
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Key Competencies
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Learning and Assessment Methods
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Recommended Reading
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Miyoshi_Index_O.pdf
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