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Preface
6
Contents
7
Igor Klatzo Lecture
14
Bulk Flow and Diffusion Revisited, and Clinical Applications
15
Ischemia and the Blood-Brain Barrier Disorders
26
Experimental Cerebral Ischemia: The Contribution of the Bethesda Group
27
Past and Recent BBB Studies with Particular Emphasis on Changes in Ischemic Brain Edema
30
Increase in Activity of Neutrophils and Proinflammatory Mediators in Rats Following Acute and Prolonged Focal Cerebral Ischemia and Reperfusion
37
Factors in Creepy Delayed Neuronal Death in Hippocampus Following Brain Ischemia– Reperfusion Injury with Long- Term Survival
44
Endogenous Pituitary Adenylate Cyclase Activating Polypeptide Is Involved in Suppression of Edema in the Ischemic Brain
49
Reduced Matrix Metalloproteinase-9 Activity and Cell Death After Global Ischemia in the Brain Preconditioned with Hyperbaric Oxygen
53
Radiation Exposure Prior to Ischemia Decreases Lesion Volume, Brain Edema and Cell Death
56
Effects of VEGF Administration or Neutralization on the BBB of Developing Rat Brain
59
Alterations in Blood–Brain Barrier Function and Brain Pathology by Morphine in the Rat. Neuroprotective Effects of Antioxidant H- 290/ 51
64
Hydrocephalus
70
Clinical Proof of the Importance of Compliance for Hydrocephalus Pathophysiology
71
An Algorithm to Assess the Rehabilitation Potential in Patients with Chronic Hydrocephalus
76
What Can Be Found Inside Shunt Catheters
81
Glue Instead of Stitches: A Minor Change of the Operative Technique with a Serious Impact on the Shunt Infection Rate
86
Animal Experiments to Evaluate Complications of Foreign Materials on Silicone with Shunt Catheters: Preliminary Results
89
Huge Thrombosis as a Consequence of VA-Shunts
92
Does Idiopathic Normal Pressure Hydrocephalus Always Mean a Poor Prognosis?
97
Gravitational Shunt Complications After a Five-Year Follow-Up
103
Is It Possible to Minimize Overdrainage Complications with Gravitational Units in Patients with Idiopathic Normal Pressure Hydrocephalus? Protocol of the Randomized Controlled SVASONA Trial ( ISRCTN51046698)
109
Early Shunting Using the Parallel Shunt System in Hemorrhagic Hydrocephalus: In Vitro Testing of Handling, Technical Complications and Clogging Rate
112
Intracranial Irregularities Beside Hydrocephalus in H-Tx Rats
115
Co-morbidity as a Predictor of Outcome in Patients with Idiopathic Normal- Pressure Hydrocephalus
121
Subarachnoid Hemorrhage and Intracerebral Hemorrhage
125
Effects of Magnesium Sulfate Infusion on Cerebral Perfusion in Patients After Aneurysmal SAH
126
Timing of Serum Active MMP-9 and MMP-2 Levels in Acute and Subacute Phases After Spontaneous Intracerebral Hemorrhage
129
Timing of Serum Soluble HLA-G Levels in Acute and Subacute Phases After Spontaneous Intracerebral Hemorrhage
133
Minocycline Attenuates Brain Edema, Brain Atrophy and Neurological Deficits After Intracerebral Hemorrhage
138
Myocardial Dysfunction in Subarachnoid Hemorrhage: Prognostication by Echo Cardiography and Cardiac Enzymes. A Prospective Study
142
The Effects of Tetrahydrobiopterin on Intracerebral Hemorrhage- Induced Brain Injury in Mice
146
Estrogen Reduces Iron-Mediated Brain Edema and Neuronal Death
149
Imaging and Diagnosis
153
Improving Diagnostic Value of CT Examinations in Hyperacute Ischemic Stroke
154
Pattern Recognition Methods in 1H MRS Monitoring In Vivo of Normal Appearing Cerebellar Tissue After Treatment of Posterior Fossa Tumors
160
Metabolic Changes in Rat Brain Following Intracerebroventricular Injections of Streptozotocin: A Model of Sporadic Alzheimer’s Disease
165
MR Spectroscopic Evaluation of Brain Tissue Damage After Treatment for Pediatric Brain Tumors
170
The Incidence of Imaging Abnormalities after Stereotactic Radiosurgery for Cerebral Arteriovenous and Cavernous Malformations
174
Magnetic Resonance Spectroscopic Evaluation of Brain Tissue Metabolism After Irradiation for Pediatric Brain Tumors in Long- Term Survivors: A Report of Two Cases
178
Evaluation of the Late Effects of CNS Prophylactic Treatment in Childhood Acute Lymphoblastic Leukemia ( ALL) Using Magnetic Resonance Spectroscopy
182
A Non-invasive Assessment of Intracranial Volume Reserve by Measuring Cerebrospinal Fluid Volume with the Aid of CT Imaging
185
Is Neuroradiological Imaging Sufficient for Exclusion of Intracranial Hypertension in Children? Intracranial Hypertension Syndrome Without Evident Radiological Symptoms
189
Trauma and Brain Tissue Injury
195
Substance P Immunoreactivity Increases Following Human Traumatic Brain Injury
196
Hyperbaric Oxygen Preconditioning Reduces Postoperative Brain Edema and Improves Neurological Outcomes After Surgical Brain Injury
202
Following Brain Trauma, Copeptin, a Stable Peptide Derived from the AVP Precusor, Does Not Reflect Osmoregulation but Correlates with Injury Severity
206
The Effects of Selective Brain Hypothermia and Decompressive Craniectomy on Brain Edema After Closed Head Injury in Mice
210
Outcome of Patients with Severe Head Injury After Decompressive Craniectomy
215
Assessing the Neurological Outcome of Traumatic Acute Subdural Hematoma Patients with and without Primary Decompressive Craniectomies
218
Changes in the Blood–CSF Barrier in Experimental Traumatic Brain Injury
221
Dynamics of S100B Release into Serum and Cerebrospinal Fluid Following Acute Brain Injury
228
Ultrastructural and Immunochemical Studies of Glial Scar Formation in Diabetic Rats
232
Significance of Monitoring the Initial Intracranial Pressure on Hematoma Irrigation with Trephination Therapy for Acute Subdural Hematomas in Critical Conditions
237
Surgical Outcome Following a Decompressive Craniectomy for Acute Epidural Hematoma Patients Presenting with Associated Massive Brain Swelling
241
Prognosis for Severe Traumatic Brain Injury Patients Treated with Bilateral Decompressive Craniectomy
245
Posterior Fossa Brain Tissue Injury: Developmental, Neuropsychological, and Neurological Consequences of Brain Tumors in Children
251
Tumor
255
The Role of eNOS in Vascular Permeability in ENU-Induced Gliomas
256
Potential Role of CT Perfusion Parameters in the Identification of Solitary Intra- axial Brain Tumor Grading
262
Treatment
267
Neuromodulation with Pleiotropic and Multimodal Drugs – Future Approaches to Treatment of Neurological Disorders
268
Selected Combination of Neurotrophins Potentiate Neuroprotection and Functional Recovery Following Spinal Cord Injury in the Rat
272
Antibodies to Dynorphin A (1–17) Attenuate Closed Head Injury Induced Blood– Brain Barrier Disruption, Brain Edema Formation and Brain Pathology in the Rat
278
Serine Protease Inhibitor Attenuates Intracerebral Hemorrhage- Induced Brain Injury and Edema Formation in Rat
284
State-of-the-Art management and Monitoring of Brain Edema and Intracranial Hypertension in Fulminant Hepatic Failure. A Proposed Algorithm
288
Novel Free Radical Monitoring in Patients with Neurological Emergency Diseases
292
Cerebrolysin Attenuates Blood–Brain Barrier and Brain Pathology Following Whole Body Hyperthermia in the Rat
297
Chronic Hypertension Aggravates Heat Stress-Induced Brain Damage: Possible Neuroprotection by Cerebrolysin
302
Nanoparticles and Brain Edema
309
Carbon Nanotubes in Neuroscience
310
Nanowired-Drug Delivery Enhances Neuroprotective Efficacy of Compounds and Reduces Spinal Cord Edema Formation and Improves Functional Outcome Following Spinal Cord Injury in the Rat
315
A New Antioxidant Compound H-290/51 Attenuates Nanoparticle Induced Neurotoxicity and Enhances Neurorepair in Hyperthermia
323
Influence of Nanoparticles on Blood–Brain Barrier Permeability and Brain Edema Formation in Rats
330
Author Index
336
Subject Index
367
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