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Endocrine Manifestations of Systemic Autoimmune Diseases

Endocrine Manifestations of Systemic Autoimmune Diseases

of: Ronald Asherson, Sara Walker, Luis J. Jara (Eds.)

Elsevier Trade Monographs, 2008

ISBN: 9780080559322 , 340 Pages

Format: PDF

Copy protection: DRM

Windows PC,Mac OSX Apple iPad, Android Tablet PC's

Price: 165,00 EUR



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Endocrine Manifestations of Systemic Autoimmune Diseases


 

Cover

1

Table of contents

8

Preface

16

Chapter 1. Introduction

20

1.1 Statistics Defined

20

1.2 Types of Statistics

20

1.3 Levels of Discourse: Sample vs. Population

21

1.4 Levels of Discourse: Target vs. Sampled Population

23

1.5 Measurement Scales

24

1.6 Sampling and Sampling Errors

26

1.7 Exercises

26

Chapter 2. Elementary Descriptive Statistical Techniques

28

2.1 Summarizing Sets of Data Measured on a Ratio or Interval Scale

28

2.2 Tabular Methods

30

2.3 Quantitative Summary Characteristics

35

2.4 Correlation between Variables X and Y

57

2.5 Rank Correlation between Variables X and Y

61

2.6 Exercises

65

Chapter 3. Probability Theory

72

3.1 Mathematical Foundations: Sets, Set Relations, and Functions

72

3.2 The Random Experiment, Events, Sample Space, and the Random Variable

78

3.3 Axiomatic Development of Probability Theory

81

3.4 The Occurrence and Probability of an Event

83

3.5 General Addition Rule for Probabilities

84

3.6 Joint, Marginal, and Conditional Probability

85

3.7 Classification of Events

91

3.8 Sources of Probabilities

96

3.9 Bayes’ Rule

98

3.10 Exercises

101

Chapter 4. Random Variables and Probability Distributions

112

4.1 Random Variables

112

4.2 Discrete Probability Distributions

113

4.3 Continuous Probability Distributions

120

4.4 Mean and Variance of a Random Variable

125

4.5 Chebyshev’s Theorem for Random Variables

130

4.6 Moments of a Random Variable

132

4.7 Quantiles of a Probability Distribution

136

4.8 Moment-Generating Function

138

4.9 Probability-Generating Function

146

4.10 Exercises

151

Chapter 5. Bivariate Probability Distributions

166

5.1 Bivariate Random Variables

166

5.2 Discrete Bivariate Probability Distributions

166

5.3 Continuous Bivariate Probability Distributions

173

5.4 Expectations and Moments of Bivariate Probability Distributions

181

5.5 Chebyshev’s Theorem for Bivariate Probability Distributions

188

5.6 Joint Moment–Generating Function

188

5.7 Exercises

193

Chapter 6. Discrete Parametric Probability Distributions

206

6.1 Introduction

206

6.2 Counting Rules

207

6.3 Discrete Uniform Distribution

213

6.4 The Bernoulli Distribution

214

6.5 The Binomial Distribution

216

6.6 The Multinomial Distribution

222

6.7 The Geometric Distribution

225

6.8 The Negative Binomial Distribution

227

6.9 The Poisson Distribution

231

6.10 The Hypergeometric Distribution

237

6.11 The Generalized Hypergeometric Distribution

244

6.12 Exercises

245

Chapter 7. Continuous Parametric Probability Distributions

254

7.1 Introduction

254

7.2 The Uniform Distribution

255

7.3 The Normal Distribution

257

7.4 The Normal Approximation to Binomial Probabilities

272

7.5 The Normal Approximation to Poisson Probabilities

276

7.6 The Exponential Distribution

277

7.7 Gamma and Beta Functions

283

7.8 The Gamma Distribution

285

7.9 The Beta Distribution

289

7.10 Other Useful Continuous Distributions

295

7.11 Exercises

304

Chapter 8. Sampling and the Sampling Distribution of a Statistic

312

8.1 The Purpose of Random Sampling

312

8.2 Sampling Scenarios

313

8.3 The Arithmetic of Random Sampling

320

8.4 The Sampling Distribution of a Statistic

325

8.5 The Sampling Distribution of the Mean

327

8.6 A Weak Law of Large Numbers

335

8.7 Convergence Concepts

338

8.8 A Central Limit Theorem

341

8.9 The Sampling Distribution of a Proportion

345

8.10 The Sampling Distribution of the Variance

352

8.11 A Note on Sample Moments

357

8.12 Exercises

361

Chapter 9. The Chi-Square, Student’s t, and Snedecor’s F Distributions

368

9.1 Derived Continuous Parametric Distributions

368

9.2 The Chi-Square Distribution

369

9.3 The Sampling Distribution of the Variance When Sampling from a Normal Population

373

9.4 Student’s t Distribution

376

9.5 Snedecor’s F Distribution

381

9.6 Exercises

387

Chapter 10. Point Estimation and Properties of Point Estimators

392

10.1 Statistics as Point Estimators

392

10.2 Desirable Properties of Estimators as Statistical Properties

394

10.3 Small Sample Properties of Point Estimators

395

10.4 Large Sample Properties of Point Estimators

427

10.5 Techniques for Finding Good Point Estimators

438

10.6 Exercises

450

Chapter 11. Interval Estimation and Confidence Interval Estimates

458

11.1 Interval Estimators

458

11.2 Central Confidence Intervals

460

11.3 The Pivotal Quantity Method

461

11.4 A Confidence Interval for µ Under Random Sampling from a Normal Population with Known Variance

462

11.5 A Confidence Interval for µ Under Random Sampling from a Normal Population with Unknown Variance

465

11.6 A Confidence Interval for s2 Under Random Sampling from a Normal Population with Unknown Mean

466

11.7 A Confidence Interval for p Under Random Sampling from a Binomial Population

470

11.8 Joint Estimation of a Family of Population Parameters

474

11.9 Confidence Intervals for the Difference of Means When Sampling from Two Independent Normal Populations

477

11.10 Confidence Intervals for the Difference of Means When Sampling from Two Dependent Populations: Paired Comparisons

483

11.11 Confidence Intervals for the Difference of Proportions When Sampling from Two Independent Binomial Populations

489

11.12 Confidence Interval for the Ratio of Two Variances When Sampling from Two Independent Normal Populations

490

11.13 Exercises

492

Chapter 12. Tests of Parametric Statistical Hypotheses

502

12.1 Statistical Inference Revisited

502

12.2 Fundamental Concepts for Testing Statistical Hypotheses

503

12.3 What Is the Research Question?

505

12.4 Decision Outcomes

506

12.5 Devising a Test for a Statistical Hypothesis

507

12.6 The Classical Approach to Statistical Hypothesis Testing

510

12.7 Types of Tests or Critical Regions

512

12.8 The Essentials of Conducting a Hypothesis Test

514

12.9 Hypothesis Test for µ Under Random Sampling from a Normal Population with Known Variance

515

12.10 Reporting Hypothesis Test Results

520

12.11 Determining the Probability of a Type II Error ß

523

12.12 Hypothesis Tests for µ Under Random Sampling from a Normal Population with Unknown Variance

529

12.13 Hypothesis Tests for p Under Random Sampling from a Binomial Population

531

12.14 Hypothesis Tests for s2 Under Random Sampling froma Normal Population

535

12.15 The Operating Characteristic and Power Functions of a Test

538

12.16 Determining the Best Test for a Statistical Hypothesis

547

12.17 Generalized Likelihood Ratio Tests

556

12.18 Hypothesis Tests for the Difference of Means When Sampling from Two Independent Normal Populations

565

12.19 Hypothesis Tests for the Difference of Means When Sampling from Two Dependent Populations: Paired Comparisons

572

12.20 Hypothesis Tests for the Difference of Proportions When Sampling from Two Independent Binomial Populations

574

12.21 Hypothesis Tests for the Difference of Variances When Sampling from Two Independent Normal Populations

576

12.22 Hypothesis Tests for Spearman’s Rank Correlation Coefficient .S

578

12.23 Exercises

580

Chapter 13. Nonparametric Statistical Techniques

588

13.1 Parametric vs. Nonparametric Methods

588

13.2 Tests for the Randomness of a Single Sample

591

13.3 Single-Sample Sign Test Under Random Sampling

599

13.4 Wilcoxon Signed Rank Test of a Median

602

13.5 Runs Test for Two Independent Samples

606

13.6 Mann-Whitney (Rank-Sum) Test for Two Independent Samples

609

13.7 The Sign Test When Sampling from Two Dependent Populations: Paired Comparisons

616

13.8 Wilcoxon Signed Rank Test When Sampling from Two Dependent Populations: Paired Comparisons

618

13.9 Exercises

622

Chapter 14. Testing Goodness of Fit

628

14.1 Distributional Hypotheses

628

14.2 The Multinomial Chi-Square Statistic: Complete Specification of H0

628

14.3 The Multinomial Chi-Square Statistic: Incomplete Specification of H0

635

14.4 The Kolmogorov-Smirnov Test for Goodness of Fit

640

14.5 The Lilliefors Goodness-of-Fit Test for Normality

649

14.6 The Shapiro-Wilk Goodness-of-Fit Test for Normality

650

14.7 The Kolmogorov-Smirnov Test for Goodness of Fit: Two Independent Samples

651

14.8 Assessing Normality via Sample Moments

653

14.9 Exercises

657

Chapter 15. Testing Goodness of Fit: Contingency Tables

662

15.1 An Extension of the Multinomial Chi-Square Statistic

662

15.2 Testing Independence

662

15.3 Testing k Proportions

668

15.4 Testing for Homogeneity

670

15.5 Measuring Strength of Association in Contingency Tables

674

15.6 Testing Goodness of Fit with Nominal-Scale Data: Paired Samples

680

15.7 Exercises

683

Chapter 16. Bivariate Linear Regression and Correlation

688

16.1 The Regression Model

688

16.2 The Strong Classical Linear Regression Model

689

16.3 Estimating the Slope and Intercept of the Population Regression Line

692

16.4 Mean, Variance, and Sampling Distribution of the LeastSquares Estimators . ß0 and . ß1

695

16.5 Precision of the Least Squares Estimators . ß0, . ß1:Confidence Intervals

698

16.6 Testing Hypotheses Concerning ß0, ß1

699

16.7 The Precision of the Entire Least Squares Regression Equation: A Confidence Band

703

16.8 The Prediction of a Particular Value of Y Given X

706

16.9 Decomposition of the Sample Variation of Y

710

16.10 The Correlation Model

714

16.11 Estimating the Population Correlation Coefficient .

716

16.12 Inferences about the Population Correlation Coefficient .

717

16.13 Exercises

724

Appendix A

736

Solutions to Selected Exercises

786

References and Suggested Reading

804

Index

808