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Neurodegeneration and Neuroprotection in Parkinson's Disease
of: C. W. Olanow, Peter Jenner, Moussa Youdim (Eds.)
Elsevier Trade Monographs, 1996
ISBN: 9780080537412 , 224 Pages
Format: PDF
Copy protection: DRM
Front Cover
1
Neurodegeneration and Neuroprotection in Parkinson's Disease
4
Copyright Page
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Contents
6
Contributors
10
Series Preface
12
Preface
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Section 1: Oxidant Stress
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Chapter 1. Oxidative stress, brain iron and neurodegeneration. Basic principles
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1.1 Life in oxygen: a brief comment
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1.2 The basic chemistry
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1.3 Antioxidant protection
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1.4 Brain iron and free radicals
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1.5 Oxidative stress: the molecular targets
28
1.6 Oxidative stress in neurodegenerative diseases
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1.7 Conclusions
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Chapter 2. Pathological evidence for oxidative stress in Parkinson's disease and related degenerative disorders
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2.1 Introduction
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2.2 Alterations in iron in PD
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2.3 Alterations in mitochondrial function
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2.4 Alterations occurring in protective enzyme systems
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2.5 Alterations in glutathione content
46
2.6 Oxidative damage in PD
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2.7 Role of levodopa in alterations in indices of oxidative stress
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2.8 Oxidative stress and incidental Lewy body disease
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2.9 Other related studies
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2.10 Which comes first? The horse or the cart?
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2.11 Which free radical species are involved in PD?
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2.12 Interrelationship of oxidant stress with other mechanisms of cell death
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2.13 Conclusions
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Chapter 3. Treatment of Parkinson's disease with deprenyl (selegiline) and other monoamine oxidase inhibitors
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3.1 Introduction
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3.2 Characteristics of MAOs
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3.3 Development of MAO inhibitors
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3.4 Deprenyl in PD
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3.5 Basis for neuroprotective action
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3.6 Clinical trials with MAO inhibitors in early PD
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3.7 Neuroprotection versus symptomatic benefit
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Chapter 4. Iron and neurodegeneration: prospects for neuroprotection
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4.1 Introduction
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4.2 Iron and the brain
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4.3 Iron and neurodegeneration
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4.4 Neuroprotection
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Chapter 5. Nitrone radical traps protect in experimental neurodegenerative diseases
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5.1 Introduction
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5.2 Background
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5.3 Recent experimental observations
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5.4 Mechanisms of NRT protective action
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Chapter 6. Therapeutic effects of nitric oxide synthase inhibition in neuronal injury
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6.1 Introduction
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6.2 Toxic effects of NO
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6.3 NO in ischaemia
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6.4 Neuronal NOS inhibitors
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6.5 Cellular mechanisms of NO toxicity
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6.6 Inducible NOS inhibitors
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6.7 Conclusions
114
Section 2: Mitochondrial Toxicity
118
Chapter 7. Mitochondrial dysfunction in neurodegeneration: prospects for neuroprotection
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7.1 Introduction
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7.2 The mitochondrial respiratory chain and oxidative phosphorylation system
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7.3 Diseases of the mitochondrial respiratory chain and mutations of mtDNA
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7.4 Parkinson's disease
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7.5 Complex I deficiency and the cause of PD
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7.6 Mechanism of cell death in PD
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7.7 Neuroprotective strategies
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7.8 Neuroprotection and the cytotoxic theory
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7.9 Conclusions
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Section 3: Excitatory Neurotoxicity
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Chapter 8. Bioenergetics and excitotoxicity: the weak excitotoxic hypothesis
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8.1 Introduction
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8.2 Neuronal energy metabolism
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8.3 Metabolic impairment and neurodegenerative disease
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8.4 Excitotoxicity and neurodegenerative disease
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8.5 The weak excitotoxic hypothesis
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8.6 Conclusions
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Section 4: Calcium Excitatory Toxicity
158
Chapter 9. Calciumions in necrotic and apoptotic cell death
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9.1 Introduction
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9.2 Intracellular Ca 2+ homeostasis and signalling
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9.3 Interference with cell signalling
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9.4 Effects of cellular Ca 2+ overload
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9.5 Role of Ca 2+ in apoptotic cell killing
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9.6 Ca 2+ overload in neuronal cell death
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9.7 Concluding remarks
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Section 5: Trophic Factors
174
Chapter 10. Neurotrophic factors: towards a restorative therapy of Parkinson's disease
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10.1 Introduction
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10.2 Neurotrophic factors
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10.3 Neurotrophic factors and dopaminergic systems
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10.4 Neurotrophic factors and non-dopaminergic systems that degenerate in PD
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10.5 The challenge of delivering protein growth factors to the brain
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10.6 Transplantation and trophic factors in PD
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10.7 Conclusion and future directions
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Section 6: Immune Mechanisms
202
Chapter 11. Immune-mediated cell death and neuroprotection in neurodegenerative diseases
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11.1 Introduction
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11.2 Amyotrophic lateral sclerosis
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11.3 Neurotrophic factors as neuroprotective agents
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11.4 Parkinson's disease
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11.5 Neuroprotective action of neurotophic factors
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Section 7: Apoptosis
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Chapter 12. Reduction of neuronal apoptosis by small molecules: promise for new approaches to neurological therapy
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12.1 Nerve cell death and nervous system disorders
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12.2 Trophic and trophic-like agents and neuronal apoptosis
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Index
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